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Invitrogen™ SHARPIN Polyclonal Antibody
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Catalog No. PIPA599964
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100 μL
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PIPA599964 100 μL
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Catalog No. PIPA599964 Supplier Invitrogen™ Supplier No. PA599964
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SHARPIN.

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHARPIN
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SHARPIN
Gene Accession No. Q91WA6, Q9EQL9, Q9H0F6
Gene Alias 0610041B22Rik; AW121341; Conneck1; cpdm; hSIPL1; mSIPL1; protein kinase C-interacting protein RBCC like 1; PSEC0216; RBCKL1; SHANK associated RH domain interactor; SHANK-associated RH domain interacting protein; SHANK-associated RH domain interactor; shank-associated RH domain-interacting protein; shank-interacting protein; shank-interacting protein-like 1; SHARPIN; SIPL1
Gene Symbols SHARPIN
Host Species Rabbit
Immunogen A synthesized peptide derived from human SHARPIN(Accession Q9H0F6), corresponding to amino acid residues G66-V116.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 106025, 81858, 81859
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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