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SHC1 Monoclonal Antibody (OTI1D3), TrueMAB™, OriGene
SDP

Catalog No. 501672217
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50-167-2217 100 μL
50-254-2556 30 μL
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Catalog No. 50-167-2217 Supplier OriGene Supplier No. TA501074
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Description

Mouse Monoclonal Antibody

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Specifications

Antigen SHC1
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI1D3
Concentration 0.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene SHC1
Gene Accession No. P29353
Gene Alias SHC, SHCA
Gene Symbols SHC1
Host Species Mouse
Immunogen Full length human recombit protein of human SHC1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6464
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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