SHC2/Sck Rabbit anti-Human∣Mouse∣Rat, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS12144R

Catalog No. 50-198-1979

Description

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.

Specifications

• Antigen: SHC2/Sck
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHC2
• Gene Alias: 6720466E06; neuronal Shc adaptor homolog; Protein Sck; Protein Sli; Sck; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; Sli; src homology 2 domain-containing transforming protein C2; Src homology 2 domain-containing-transforming protein C2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 216148, 25759, 314612
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: O70142, P98077, Q8BMC3
• Gene Symbols: SHC2
• Immunogen: KLH conjugated synthetic peptide derived from human SHC2/Sck.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG