PLAU, Sheep, Polyclonal Antibody, Abnova
Sheep polyclonal antibody raised against native PLAU.
Manufacturer: Abnova Corporation PAB14929
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
|The optimal working dilution should be determined by the end user.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody reacts only with human u-PA isolated from kidney cell culture tissue. No reactivity with other human proteins. Identity established by double diffusion with u-PA isolated from human kidney tissue and E. coli-derived recombinant u-PA. No cross reactivity with human tissue type plasminogen activator.|
|ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation, Inhibition Assays, Radioimmune Assays, Western Blot|
|Sheep polyclonal antibody raised against native PLAU.|
|Native purified two chain human urinary type high molecular weight PLAU from pooled urine.|
For Research Use Only