Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PLAU, Sheep, Polyclonal Antibody, Abnova™

Sheep polyclonal antibody raised against native PLAU.

Manufacturer:  Abnova Corporation PAB14929

Catalog No. 89-117-352


Add to cart

Description

Description

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Specifications

PLAU
Unconjugated
The optimal working dilution should be determined by the end user.
PLAU
ATF|UPA|URK|UROKINASE|u-PA
Sheep
1 mL
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
This antibody reacts only with human u-PA isolated from kidney cell culture tissue. No reactivity with other human proteins. Identity established by double diffusion with u-PA isolated from human kidney tissue and E. coli-derived recombinant u-PA. No cross reactivity with human tissue type plasminogen activator.
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation, Inhibition Assays, Radioimmune Assays, Western Blot
Sheep polyclonal antibody raised against native PLAU.
In serum
Liquid
PLAU
Native purified two chain human urinary type high molecular weight PLAU from pooled urine.
RUO
Primary
5328
Human
SDS
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only