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SNCA Sheep anti-Human, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89114410 Shop All Abnova Corporation Products
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89-114-410 50 μg
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Catalog No. 89-114-410 Supplier Abnova Corporation Supplier No. PAB0770
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Sheep polyclonal antibody raised against synthetic peptide of SNCA.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]

Sequence: PQEGILEDMPVDPC

Specifications

Antigen SNCA
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Sheep polyclonal antibody raised against synthetic peptide of SNCA.
Dilution Immunohistochemistry (1 ug/mL) The optimal working dilution should be determined by the end user.
Formulation Lyophilized from PBS
Gene SNCA
Gene Alias MGC110988/NACP/PARK1/PARK4/PD1
Gene Symbols SNCA
Host Species Sheep
Immunogen A synthetic peptide (conjugated diphtheria toxoid) corresponding to amino acids 108-120 of human SNCA.
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6622
Test Specificity Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot.
Target Species Human, Rat
Content And Storage Store at 4°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Form Lyophilized
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