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Invitrogen™ SHFM3 Polyclonal Antibody
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Catalog No. PIPA596951
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100 μL
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PIPA596951 100 μL
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Catalog No. PIPA596951 Supplier Invitrogen™ Supplier No. PA596951
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QFRPDGASLN RRPLGVFAGH DEDVCHFVLA NSHIVSAGGD GKIGIHKIHS TFTVKYSAHE QEVNCVDCKG GIIVSGSRDR TAKVWPLASG RLGQCLHTIQ TEDRVWSIAI SPLLSSFVTG TACCGHFSPL RIWDLNSGQL MTHLGSDFPP GAGVLDVMYE SPFTLLSCGY DTYVRYWDLR TSVRKCVMEW EEPHDSTLYC LQTDGNHLLA TGSSYYGVVR LWDRRQRACL HAFPLTSTPL SSPVYCLRLT TKHLYAALSY NLHVLDFQNP; Positive Samples: Mouse brain.

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHFM3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.56 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FBXW4
Gene Accession No. Q9JMJ2
Gene Alias Dac; dactylaplasia; dactylin; dactylyn; F-box and WD repeat domain containing 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box protein Fbw4; F-box/WD repeat protein 4; F-box/WD repeat-containing protein 4; FBW4; FBWD4; FBXW4; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 4; protein hagoromo; SHFM3; SHSF3
Gene Symbols FBXW4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 143-412 of human FBXW4 (NP_0713221).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30838
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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