SHFM3 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-8522	100 μL

Catalog No. 50-198-8522 Supplier Bioss Supplier No. BS8390R

Description

Rabbit Polyclonal Antibody

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

Specifications

• Antigen: SHFM3
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: FBXW4
• Gene Accession No.: P57775
• Gene Alias: BOS_23470; DAC; dactylaplasia; Dactylin; dactylyn; F-box and WD repeat domain containing 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box protein Fbw4; F-box/WD repeat protein 4; F-box/WD repeat-containing protein 4; FBW4; FBWD4; FBXW4; Protein hagoromo; SHFM3; SHSF3
• Gene Symbols: FBXW4
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human SHFM3.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6468
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG