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Invitrogen™ Shiga toxin 2A Monoclonal Antibody (B19J)
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Catalog No. MA17101
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MA17101 1 mL
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Catalog No. MA17101 Supplier Invitrogen™ Supplier No. MA17101
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Description

Mouse Monoclonal Antibody

MA1-7101 detects the Verotoxin. This antibody is specific for Verotoxin II - A subunit (SLT-2a). MA1-7101 has been successfully used in ELISA procedures. The MA1-7101 immunogen is purified native toxoid.

Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Shiga toxin 2A
Applications ELISA
Classification Monoclonal
Clone B19J
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.2
Gene Alias Shiga toxin; Shigatoxin Type 2; Shigatoxin Type II; STX2; STX-2a; STX-IIa
Host Species Mouse
Immunogen Purified native toxoid.
Purification Method Protein A
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Bacteria
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2
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