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Invitrogen™ SHISA3 Polyclonal Antibody
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Catalog No. PIPA5116165
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400 μL
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PIPA5116165 400 μL
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Catalog No. PIPA5116165 Supplier Invitrogen™ Supplier No. PA5116165
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Description

Rabbit Polyclonal Antibody

SHISA3 Polyclonal Antibody for Western Blot, IHC (P)

SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHISA3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene SHISA3
Gene Accession No. A0PJX4, Q3UPR0
Gene Alias D830007B15Rik; hShisa3; Protein shisa-3 homolog; RGD1565710; shisa family member 3; shisa homolog 3; Shisa3
Gene Symbols SHISA3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 158-186 amino acids from the C-terminal region of human SHISA3.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 152573, 330096
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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