Invitrogen™ SHISA3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534527

Catalog No. PIPA534527

Description

A suggested positive control is human small intestine tissue lysate. PA5-34527 can be used with blocking peptide PEP-1570.

SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Specifications

• Antigen: SHISA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHISA3
• Gene Alias: D830007B15Rik; hShisa3; Protein shisa-3 homolog; RGD1565710; shisa family member 3; shisa homolog 3; Shisa3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 152573, 330096, 498356
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: A0PJX4, Q3UPR0
• Gene Symbols: SHISA3
• Immunogen: A 15 amino acid peptide near the center of human SHISA3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov