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Invitrogen™ SHISA3 Polyclonal Antibody
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Catalog No. PIPA534527
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100 μg
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Catalog No. Quantity
PIPA534527 100 μg
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Catalog No. PIPA534527 Supplier Invitrogen™ Supplier No. PA534527
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human small intestine tissue lysate. PA5-34527 can be used with blocking peptide PEP-1570.

SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHISA3
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SHISA3
Gene Accession No. A0PJX4, Q3UPR0
Gene Alias D830007B15Rik; hShisa3; Protein shisa-3 homolog; RGD1565710; shisa family member 3; shisa homolog 3; Shisa3
Gene Symbols SHISA3
Host Species Rabbit
Immunogen A 15 amino acid peptide near the center of human SHISA3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 152573, 330096, 498356
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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