SHISA3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA563016

Catalog No. PIPA563016

Description

Immunogen sequence: SNNIAIKGVA RFYRSRKKHL ITTQTEHKCV LDSCRSLEAE GFQVTYLPVQ KSGIIDLKEL EAAIQPDTSL VSVMTVNNEI GVKQPIAEIG RICSSRKV Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Specifications

• Antigen: SHISA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHISA3
• Gene Alias: SHISA3, Shisa homolog 3, hShisa3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 152573
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A0PJX4
• Gene Symbols: SHISA3
• Immunogen: Recombit protein corresponding to Human SHISA3
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only