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Invitrogen™ SHMT1 Polyclonal Antibody
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Catalog No. PIPA588581
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100 μL
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PIPA588581 100 μL
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Catalog No. PIPA588581 Supplier Invitrogen™ Supplier No. PA588581
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FKVYQHQVVA NCRALSEALT ELGYKIVTGG SDNHLILVDL RSKGTDGGRA EKVLEACSIA CNKNTCPGDR SALRPSGLRL GTPALTSRGL LEKDFQKVAH FIHRGIELTL QIQSDTGVRA TLKEFKERLA GDKYQAAVQA LREEVESFAS LFPLPGLPDF; Positive Samples: 293T, HepG2, HT-29, K-562, A375, Mouse liver; Cellular Location: Cytoplasm.

This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHMT1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Shmt1
Gene Accession No. P34896, P50431
Gene Alias AI324848; AI385541; C81125; CSHMT; cytoplasmic serine hydroxymethyltransferase; cytosolic form; cytosolic serine hydroxymethyltransferase; F20D10.50; F20D10_50; glycine hydroxymethyltransferase; LRRGT00032; MEL-32; MGC15229; MGC24556; mshmt; mshmt1; mshmt2; serine hydroxymethyl transferase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 1; serine hydroxymethyltransferase 1 (soluble); serine hydroxymethyltransferase 1 (soluble) isoform 1; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, cytosolic; Serine methylase; SERINE TRANSHYDROXYMETHYLASE; SERINE TRANSHYDROXYMETHYLTRANSFERASE; serine transhydroxymethyltransferase 1; SHM1; SHMT; Shmt1; shmt1 protein; SHMT2; STM; zgc:66171; zgc:77524; zSHMT-1
Gene Symbols Shmt1
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20425, 287379, 6470
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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