Invitrogen™ SHMT2 Monoclonal Antibody (OTI1E12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527057

Catalog No. PIMA527057

Description

SHMT2 Monoclonal Antibody for Western Blot, IHC (P)

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.

Specifications

• Antigen: SHMT2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P34897, Q9CZN7
• Gene Symbols: SHMT2
• Immunogen: Full length human recombinant protein of SHMT2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E12
• Conjugate: Unconjugated
• Gene: SHMT2
• Gene Alias: 2700043D08Rik; AA408223; AA986903; epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; SHMT2; threonine aldolase
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108037, 299857, 6472
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid