SHMT2 Mouse anti-Human, Clone: OTI1E12, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF808813

Catalog No. 50-166-9095

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.

Specifications

• Antigen: SHMT2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SHMT2
• Gene Alias: GLYA, HEL-S-51e, SHMT
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6472
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P34897
• Gene Symbols: SHMT2
• Immunogen: Full length human recombit protein of human SHMT2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1