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Invitrogen™ SHMT2 Polyclonal Antibody
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Catalog No. PIPA554230
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100 μL
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PIPA554230 100 μL
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Catalog No. PIPA554230 Supplier Invitrogen™ Supplier No. PA554230
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GQLVRMAIRA QHSNAAQTQT GEANRGWTGQ ESLSDSDPEM WELLQREKDR QCRGLELIAS ENFCSRAALE AL Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHMT2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SHMT2
Gene Accession No. P34897, Q9CZN7
Gene Alias 2700043D08Rik; AA408223; AA986903; epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; SHMT2; threonine aldolase
Gene Symbols SHMT2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SHMT2. Recombinant protein control fragment (Product #RP-91764).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108037, 299857, 6472
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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