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Invitrogen™ SHMT2 Polyclonal Antibody
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Catalog No. PIPA5120145
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100 μL
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PIPA5120145 100 μL
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Catalog No. PIPA5120145 Supplier Invitrogen™ Supplier No. PA5120145
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, 293T, SW620. The target is usually found in the following locations: Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix, mitochondrion nucleoid.

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHMT2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.32 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene SHMT2
Gene Accession No. P34897
Gene Alias 2700043D08Rik; AA408223; AA986903; epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; SHMT2; threonine aldolase
Gene Symbols SHMT2
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6472
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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