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Invitrogen™ SHMT2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA532228
Description
Recommended positive controls: 293T, HeLa, A431, HepG2. Predicted reactivity: Mouse (93%), Rat (91%), Xenopus laevis (81%), Rabbit (93%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
Specifications
SHMT2 | |
Polyclonal | |
Unconjugated | |
SHMT2 | |
2700043D08Rik; AA408223; AA986903; epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; SHMT2; threonine aldolase | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
108037, 299857, 6472 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 20% glycerol and 0.01% thimerosal; pH 7 | |
P34897, Q9CZN7 | |
SHMT2 | |
Recombinant protein fragment corresponding to a region within amino acids 1 and 483 of Human SHMT2. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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