Invitrogen™ SHOC2 Polyclonal Antibody

Catalog No.	Quantity
PIPA578243	100 μL

Catalog No. PIPA578243 Supplier Invitrogen™ Supplier No. PA578243

Description

Rabbit Polyclonal Antibody

Positive Control: A431 Predicted Reactivity: Rat (100%), Zebrafish (97%), Xenopus laevis (100%), Rhesus Monkey (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Specifications

• Antigen: SHOC2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.38 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: Shoc2
• Gene Accession No.: O88520, Q9UQ13
• Gene Alias: AU017287; KIAA0862; Leucine-rich repeat protein SHOC-2; mKIAA0862; Protein soc-2 homolog; protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; Shoc2; SHOC2 leucine-rich repeat scaffold protein; SHOC2, leucine rich repeat scaffold protein; SIAA0862; SOC2; soc-2 (suppressor of clear) homolog; soc-2 (suppressor of clear) homolog (C. elegans); soc-2 suppressor of clear homolog; soc-2 suppressor of clear homolog (C. elegans); suppressor of clear, C. elegans, homolog of; SUR8
• Gene Symbols: Shoc2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human SHOC2. The exact sequence is proprietary.
• Purification Method: Antigen Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56392, 8036
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG