Invitrogen™ SHOC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596278

Catalog No. PIPA596278

Description

Immunogen sequence: MSSSLGKEKD SKEKDPKVPS AKEREKEAKA SGGFGKESKE KEPKTKGKDA KDGKKDSSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE NSMRLDLSKR SIHILPSSIK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR FNRITTVEKD IKNLSKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL EHLPKEIGNC TQITNLDLQH NELLDLPDTI; Positive Samples: U87, Jurkat, MCF7, Mouse brain, Mouse lung, Mouse spleen, Rat testis; Cellular Location: Cytoplasm, Nucleus.

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Specifications

• Antigen: SHOC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Shoc2
• Gene Alias: AU017287; KIAA0862; Leucine-rich repeat protein SHOC-2; mKIAA0862; Protein soc-2 homolog; protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; Shoc2; SHOC2 leucine-rich repeat scaffold protein; SHOC2, leucine rich repeat scaffold protein; SIAA0862; SOC2; soc-2 (suppressor of clear) homolog; soc-2 (suppressor of clear) homolog (C. elegans); soc-2 suppressor of clear homolog; soc-2 suppressor of clear homolog (C. elegans); suppressor of clear, C. elegans, homolog of; SUR8
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309548, 56392, 8036
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.67 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O88520, Q6AYI5, Q9UQ13
• Gene Symbols: Shoc2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_0313992).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG