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Invitrogen™ SHOC2 Polyclonal Antibody
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Catalog No. PIPA520762
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100 μg
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Catalog No. Quantity
PIPA520762 100 μg
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Catalog No. PIPA520762 Supplier Invitrogen™ Supplier No. PA520762
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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-20762 can be used with blocking peptide PEP-0876.

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHOC2
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Shoc2
Gene Accession No. O88520, Q6AYI5, Q9UQ13
Gene Alias AU017287; KIAA0862; Leucine-rich repeat protein SHOC-2; mKIAA0862; Protein soc-2 homolog; protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; Shoc2; SHOC2 leucine-rich repeat scaffold protein; SHOC2, leucine rich repeat scaffold protein; SIAA0862; SOC2; soc-2 (suppressor of clear) homolog; soc-2 (suppressor of clear) homolog (C. elegans); soc-2 suppressor of clear homolog; soc-2 suppressor of clear homolog (C. elegans); suppressor of clear, C. elegans, homolog of; SUR8
Gene Symbols Shoc2
Host Species Rabbit
Immunogen A 21 amino acid peptide near the amino terminus of human SHOC2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 309548, 56392, 8036
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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