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Invitrogen™ Shootin1 Polyclonal Antibody
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Catalog No. PIPA5111091
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100 μL
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PIPA5111091 100 μL
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Catalog No. PIPA5111091 Supplier Invitrogen™ Supplier No. PA5111091
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKEN Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 98%.

SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Shootin1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.30 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SHTN1
Gene Accession No. A0MZ66, A0MZ67
Gene Alias 4930506M07Rik; Kiaa1598; mKIAA1598; RGD1311558; RIKEN cDNA 4930506M07 gene; shootin 1; Shootin1; shootin-1; shot1; Shtn1; similar to 4930506M07Rik protein
Gene Symbols SHTN1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human Shootin1. Recombinant protein control fragment (Product #RP-97202).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 292139, 57698
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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