Invitrogen™ SHOX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596999

Catalog No. PIPA596999

Description

Immunogen sequence: ELDMGAAERS REPGSPRLTE GRRKPTKAEV QATLLLPGEA FRFLVSPELK DRKEDAKGME DEGQTKIKQR RSRTNFTLEQ LNELERLFDE THYPDAFMRE ELSQRLGLSE ARVQVWFQNR RAKCRKQENQ LHKGVLIGAA SQFEACRVAP YVNVGALRMP FQQDSHCNVT PLSFQVQAQL QLDSAVAHAH HHLHPHLAAH APYMMFPAPP FGLPLATLAA DSASAASVVA AAAAAKTTSK NSSIADLRLK AKKHAAALGL; Positive Samples: NCI-H460, Mouse skeletal muscle, Mouse liver; Cellular Location: Nucleus.

SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

Specifications

• Antigen: SHOX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHOX2
• Gene Alias: 6330543G17Rik; Homeobox protein Og12X; OG12; OG-12; Og12x; OGI2X; Paired family homeodomain protein Prx3; paired-related homeobox protein SHOT; Prx3; short stature homeobox 2; short stature homeobox protein 2; SHOT; SHOX homologous gene on chromosome 3; Shox2; similar to short stature homeobox 2; zgc:65884; zgc:77344
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20429, 25546, 6474
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O35750, O60902, P70390
• Gene Symbols: SHOX2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 96-355 of human SHOX2 (NP_0030213).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG