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SHP-1 Monoclonal Antibody (1SH01 (11D7C8H5)), Invitrogen™

Catalog No. PIMA511669
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500 μL
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Catalog No. Quantity
PIMA511669 500 μL
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Catalog No. PIMA511669 Supplier Thermo Scientific Supplier No. MA511669

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

MA5-11669 targets SHP-1 in WB applications and shows reactivity with Human samples. The MA5-11669 immunogen is recombinant human SHP1 protein.

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHP-1
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 1SH01 (11D7C8H5)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene PTPN6
Gene Accession No. P29350
Gene Alias 70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols PTPN6
Host Species Mouse
Immunogen Recombinant human SHP1 protein
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5777
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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