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Invitrogen™ SHP-1 Monoclonal Antibody (B5-A4)
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Catalog No. PIMA542574
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100 μL
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PIMA542574 100 μL
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Catalog No. PIMA542574 Supplier Invitrogen™ Supplier No. MA542574
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Description

Mouse Monoclonal Antibody

Positive Control: Mouse tonsil, human tonsil, mouse lymphoid tissue Subcellular Location: Cytoplasm, nucleus.

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
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Specifications

Antigen SHP-1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone B5-A4
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PTPN6
Gene Accession No. P29350, P29351, P81718
Gene Alias 70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6
Gene Symbols PTPN6
Host Species Mouse
Immunogen Recombinant protein within human shp1 aa 400-590.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116689, 15170, 5777
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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