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Invitrogen™ SIAH1/SIAH2 Monoclonal Antibody (8G7H12)
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Catalog No. PIMA524781
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500 μL
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PIMA524781 500 μL
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Catalog No. PIMA524781 Supplier Invitrogen™ Supplier No. MA524781
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Description

Mouse Monoclonal Antibody

This is specific for human SIAH 1 and 2 and Drosophila SINA in proliferating cells and stem cells. This does not detect Drosophila SINAH or normal, nondividing cells. Does not react with mouse.

SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and a slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIAH1/SIAH2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 8G7H12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with 0.1% sodium azide
Gene SIAH2
Gene Accession No. O43255, P21461, Q06986, Q7ZVG6, Q8IUQ4, Q8R4T2, Q920M9
Gene Alias AA415433; E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase SIAH2; EC 6.3.2; FLJ08065; hSIAH1; hSiah2; HUMSIAH; id:ibd2635; mSiah2; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 1A; seven in absentia 2; seven in absentia homolog 1; Seven in absentia homolog 2; SIAH; siah E3 ubiquitin protein ligase 1; siah E3 ubiquitin protein ligase 2; Siah1; siah-1; Siah1a; Siah-1a; Siah2; siah-2; Sinh2; zgc:56026
Gene Symbols SIAH1, SIAH2, sina
Host Species Mouse
Immunogen Synthetic peptide made to a C-terminal portion of the drosophila SINA protein (within residues 280-331).
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100520614, 100622531, 110337437, 140593, 140941, 20439, 39884, 6477, 6478, 80955
Target Species Human, Mouse, Rat, Pig, Drosophila, Zebrafish
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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