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Invitrogen™ SIAH1/SIAH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536274

Catalog No. PIPA536274


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Description

Description

This antibody detects endogenous protein at a molecular weight of 40 kDa. Purity is >95% by SDS-PAGE.

SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and a slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SIAH1/SIAH2
Polyclonal
Unconjugated
SIAH2
AA415433; E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase SIAH2; EC 6.3.2; FLJ08065; hSIAH1; hSiah2; HUMSIAH; id:ibd2635; mSiah2; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 1A; seven in absentia 2; seven in absentia homolog 1; Seven in absentia homolog 2; SIAH; siah E3 ubiquitin protein ligase 1; siah E3 ubiquitin protein ligase 2; Siah1; siah-1; Siah1a; Siah-1a; Siah2; siah-2; Sinh2; zgc:56026
Rabbit
Antigen Affinity Chromatography
RUO
110337437, 140593, 140941, 20439, 6477, 6478
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 15mM sodium azide; pH 7.2
O43255, Q06986, Q8IUQ4, Q8R4T2, Q920M9
SIAH1, SIAH2
Synthetic peptide corresponding to amino acids 178-229 of human Siah-1.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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