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Tocris Bioscience™ SIB 1893

mGlu5 antagonist; also positive allosteric modulator at mGlu4 receptors

Manufacturer:  Tocris Bioscience™ 1214/10

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Catalog No. 12-141-0


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Description

Description

SIB 1893 is an a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu4 receptors.
Specifications

Specifications

10 mg
SIB 1893
195.26
SIB 1893
SDS
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