Invitrogen™ SIGIRR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520078

Catalog No. PIPA520078

Description

A suggested positive control is A549 cell lysate. PA5-20078 can be used with blocking peptide PEP-0196.

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.

Specifications

• Antigen: SIGIRR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGIRR
• Gene Alias: AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8; UNQ301/PRO342
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24058, 59307
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6IA17, Q9JLZ8
• Gene Symbols: SIGIRR
• Immunogen: A synthetic peptide corresponding to 15 amino acids at the C-terminus of mouse SIGIRR.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov