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SIGIRR Polyclonal Antibody, Invitrogen™

Catalog No. PIPA129825
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200 μL
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Catalog No. Quantity
PIPA129825 200 μL
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Catalog No. PIPA129825 Supplier Thermo Scientific Supplier No. PA129825

Description

Rabbit Polyclonal Antibody

PA1-29825 detects SIGIRR from human samples.

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGIRR
Applications Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum diluted in PBS with 0.1mg/mL BSA and 0.02% sodium azide
Gene SIGIRR
Gene Accession No. Q6IA17
Gene Alias AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8; UNQ301/PRO342
Gene Symbols SIGIRR
Host Species Rabbit
Immunogen Synthetic peptides corresponding to aa 309-323 and 380-393 of human SIGIRR.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59307
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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