SIGIRR Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5768	Proteintech Group Inc 278281AP150UL	150 μL

Description

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.

Specifications

• Antigen: SIGIRR
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q6IA17, Q9JLZ8
• Gene ID (Entrez): 24058, 59307
• Immunogen: SIGIRR Fusion Protein Ag25850
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SIGIRR

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: SIGIRR, TIR8, Toll/interleukin 1 receptor 8
• Gene Symbols: SIGIRR
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody