SIGIRR Recombinant Rabbit Monoclonal Antibody (010), PE, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Thermo Scientific MA540972

Catalog No. PIMA540972

Description

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.

Specifications

• Antigen: SIGIRR
• Classification: Recombinant Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.5% BSA and 0.03% ProClin 300
• Gene Accession No.: Q6IA17
• Gene Symbols: SIGIRR
• Immunogen: Recombinant Human SIGIRR/TIR8 protein
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 010
• Conjugate: PE
• Gene: SIGIRR
• Gene Alias: AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8; UNQ301/PRO342
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 59307
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Isotype: IgG