Siglec-3/CD33 Antibody (WM53), PE/Cy7, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234511PECY7

Catalog No. N234511PEC7

Description

Siglec-3/CD33 Monoclonal specifically detects Siglec-3/CD33 in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: Siglec-3/CD33
• Classification: Monoclonal
• Conjugate: PE-Cyanine7
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: CD33
• Immunogen: Human AML cells
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
• Content And Storage: Store at 4°C in the dark. Do not freeze.

• Applications: Flow Cytometry
• Clone: WM53
• Dilution: Flow Cytometry
• Gene Alias: CD33 antigen, CD33 antigen (gp67), CD33 molecule, FLJ00391, myeloid cell surface antigen CD33, p67, sialic acid binding Ig-like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC-3, SIGLEC3gp67
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Immunology
• Gene ID (Entrez): 945.0
• Target Species: Human
• Isotype: IgG1 κ