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Siglec 7 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984752
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50-198-4752 100 μL
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Catalog No. 50-198-4752 Supplier Bioss Supplier No. BS2466R
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Description

Rabbit Polyclonal Antibody

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Specifications

Antigen Siglec 7
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SIGLEC7
Gene Accession No. Q9Y286
Gene Alias Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; Sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; Siglec-7; SIGLECP2
Gene Symbols SIGLEC7
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CD328/Siglec 7.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27036
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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