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Siglec-G Mouse, anti-Mouse, R718, Clone: SH1, BD OptiBuild™

Catalog No. BDB752262 Shop All BD Biosciences Products
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BDB752262 50 μg
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Catalog No. BDB752262 Supplier BD Biosciences Supplier No. 752262
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Description

Mouse Monoclonal Antibody

The SH1 monoclonal antibody specifically binds to mouse Siglec-G (sialic acid binding immunoglobulin-like lectin G), also known as Siglec10. Siglec-G is a Type I transmembrane glycoprotein that belongs to the Immunoglobulin superfamily. Siglec-G functions as an adhesion molecule that mediates sialic-acid dependent binding to cells. Siglec-G is expressed on cells of the B cell lineage. Siglec-G is most highly expressed by pre-B cells and B1a cells within the B cell lineage and is not detectable on T cells. Siglec-G can inhibit B cell receptor-mediated calcium signaling when it is overexpressed. Mice that lack Siglec-G have significantly increased numbers of B1a cells that begins early in development and is B cell intrinsic. Siglec-G-deficient mice have higher titers of natural IgM antibodies than their normal counterparts. Mouse Siglec-G is the ortholog of human Siglec-10 (also known as, CD330).

TRUSTED_SUSTAINABILITY

Specifications

Antigen Siglec-G
Applications Flow Cytometry
Classification Monoclonal
Clone SH1
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Refrigerate Upon Arrival
Form Liquid
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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