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Siglec-H Mouse, anti-Mouse, R718, Clone: 440C, BD OptiBuild™

Catalog No. BDB751846 Shop All BD Biosciences Products
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BDB751846 50 μg
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Catalog No. BDB751846 Supplier BD Biosciences Supplier No. 751846
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Description

Mouse Monoclonal Antibody

The 440c monoclonal antibody specifically recognizes Siglec-H, a type I transmembrane glycoprotein that is encoded by Siglech (Sialic acid binding Ig-like lectin H). Siglec-H contains two immunoglobulin domains in its extracellular region and a cytoplasmic domain that lacks tyrosine-based signaling motifs unlike other CD33-related Siglec-like molecules. Siglec-H is expressed on progenitors of plasmacytoid dendritic cells (pDCs) and depends on DAP12 for cell surface expression and intracellular signaling function. In addition to its expression on pDC, Siglec-H may also be expressed by splenic marginal zone macrophages, medullary macrophages in lymph nodes, and microglia. Siglec-H may regulate the production of type I interferons (IFN-I) by pDCs and other cell types. There is no clear human ortholog for mouse Siglec-H.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Siglec-H
Applications Flow Cytometry
Classification Monoclonal
Clone 440C
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Refrigerate Upon Arrival
Form Liquid
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