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Invitrogen™ SIGLEC11 Polyclonal Antibody
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Catalog No. PIPA563831
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100 μL
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PIPA563831 100 μL
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Catalog No. PIPA563831 Supplier Invitrogen™ Supplier No. PA563831
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YSEIKIHTGQ PLRGPGFGLQ LEREMSGMVP K Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 35%.

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC11
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SIGLEC11
Gene Accession No. Q96RL6
Gene Alias sialic acid binding Ig like lectin 11; sialic acid binding Ig-like lectin 11; sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; Siglec; SIGLEC11; siglec-11; UNQ9222/PRO28718
Gene Symbols SIGLEC11
Host Species Rabbit
Immunogen Recombinant protein fragment of Human SIGLEC11 (Product #RP-101402)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114132
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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