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SIGLEC11 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501989896
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100 μL
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50-198-9896 100 μL
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Catalog No. 50-198-9896 Supplier Bioss Supplier No. BS20001R
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Description

Rabbit Polyclonal Antibody

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist. Siglec11 antibody will not cross-react with Siglec10.

Specifications

Antigen SIGLEC11
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation TBS with 1% BSA, 50% glycerol and 0.03% Proclin 300; pH
Gene SIGLEC11
Gene Accession No. Q96RL6
Gene Alias sialic acid binding Ig like lectin 11; sialic acid binding Ig-like lectin 11; Sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; Siglec; SIGLEC11; siglec-11; UNQ9222/PRO28718
Gene Symbols SIGLEC11
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SIGLEC11.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114132
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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