Invitrogen™ SIGLEC12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531457

Catalog No. PIPA531457

Description

Recommended positive controls: MCF-7. Predicted reactivity: Chimpanzee (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.

Specifications

• Antigen: SIGLEC12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGLEC12
• Gene Alias: Cd170; MIS; mSiglec-E; Myeloid inhibitory siglec; S2V; sialic acid binding Ig like lectin 12 (gene/pseudogene); sialic acid binding Ig-like lectin 12; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin E; sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin 5; sialic acid-binding Ig-like lectin E; Sialic acid-binding Ig-like lectin-like 1; sialic acid-binding immunoglobulin-like lectin E; Siglec; SIGLEC12; siglec-12; Siglec5; Siglec-5; Siglec9; Siglece; siglec-E; Siglecl1; Siglec-L1; SIGLEC-like 1; Siglec-XII; SLG; UNQ9215/PRO34042
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 89858
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.99 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96PQ1
• Gene Symbols: SIGLEC12
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human SIGLEC12. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov