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SIGLEC12 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548763

Catalog No. PA548763

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Sialic acid-binding immunoglobulin-like lectins are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
Specifications

Specifications

SIGLEC12
Polyclonal
PBS with 0.09% sodium azide
Q96PQ1, Q91Y57
Sialic acid-binding Ig-like lectin 12, Siglec-12, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, SIGLEC12, SIGLECL1, SLG
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
83382, 89858
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SIGLEC12
Liquid
SIGLEC12, Siglece
KLH conjugated synthetic peptide between 565-595 amino acids from the C-terminal region of human SIGLEC12.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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