Invitrogen™ SIGLEC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110370

Catalog No. PIPA5110370

Description

Immunogen sequence: EKPVYELQVQ KSVTVQEGLC VLVPCSFSYP WRSWYSSPPL YVYWFRDGEI PYYAEVVATN NPDRRVKPET QGRFRLLGDV QKKNCSLSIG DARMEDTGSY FFRVERGRDV KYSYQQNKLN LEVTALIEKP DIHFLEPLES GRPTRLSCSL PGSCEAGPPL TFSWTGNALS PLDPETTRSS ELTLTPRPED HGTNLTCQMK RQGAQVTTER TVQLNVSYAP QTITIFRNGI ALEILQNTSY LPVLEGQALR LLCDAPSNPP AHLSWFQGSP ALNATPISNT GILELRRVRS AEEGGFTCRA QHPLGFLQIF LNLSVYSLPQ LLGPSCSWEA EGLHCRCSFR ARPAPSLCWR LEEKPLEGNS SQGSFKVNSS SAGPWANSSL ILHGGLSSDL KVSCKAWNIY GSQSGSVLLL QGRSNLGT.

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This molecule is expressed by monocytic/myeloid lineage cells. SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Specifications

• Antigen: SIGLEC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGLEC5
• Gene Alias: CD170; CD33 antigen-like 2; CD33L2; mSiglec-F; OB-binding protein 2; OBBP2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin F; sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin F; sialic acid-binding immunoglobulin-like lectin 5; sialic acid-binding lectin Siglec-F; Siglec; SIGLEC5; siglec-5; Siglecf; Siglec-F
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8778
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 4.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O15389
• Gene Symbols: SIGLEC5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 17-434 of human SIGLEC5 (NP_0038211).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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