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SIGLEC7 Monoclonal Antibody (OTI1G7), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA507392

Encompass_Preferred

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Catalog No. 50-167-7089


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Description

Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Specifications

Specifications

SIGLEC7
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9Y286
SIGLEC7
Full length human recombit protein of human SIGLEC7 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2b
Western Blot
OTI1G7
Unconjugated
SIGLEC7
AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
Mouse
Affinity Chromatography
RUO
27036
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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