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Invitrogen™ SIGLEC8 Monoclonal Antibody (1A5B9)
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Catalog No. FERMA548730
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100 μg
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Catalog No. Quantity
FERMA548730 100 μg
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Catalog No. FERMA548730 Supplier Invitrogen™ Supplier No. MA548730
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Description

Mouse Monoclonal Antibody

SIGLEC8 Monoclonal Antibody for Western Blot, IHC (P), Flow, ELISA

SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC8
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1A5B9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene SIGLEC8
Gene Accession No. Q9NYZ4
Gene Alias CDw329; MGC59785; SAF2; SAF-2; sialic acid binding Ig like lectin 8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; SIGLEC8; Siglec-8; SIGLEC8L
Gene Symbols SIGLEC8
Host Species Mouse
Immunogen Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27181, 292846
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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