Invitrogen™ SIGLEC8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528846

Catalog No. PIPA528846

Description

Recommended positive controls: A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.

Specifications

• Antigen: SIGLEC8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIGLEC8
• Gene Alias: CDw329; MGC59785; SAF2; SAF-2; sialic acid binding Ig like lectin 8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; SIGLEC8; Siglec-8; SIGLEC8L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27181
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NYZ4
• Gene Symbols: SIGLEC8
• Immunogen: Synthetic peptide corresponding to a region within amino acids 436 and 499 of Human SIGLEC8.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG