SIGLEC9 Mouse anti-Human, Clone: OTI8F7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500380

Catalog No. 50-165-9458

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Siglec9 (Sialic acid-binding Ig-like lectin 9) is single-pass type I membrane protein and belongs to immunoglobulin super family and contains two Ig-like C2 type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is reported that Siglec9 recognizes sialic acid in alpha2, 3-or alpha2, 6-glycosidic linkage to galactose. Using a specific antibody, Siglec9 was found to be expressed at high or intermediate levels by monocytes, neutrophils, and a minor population of CD16+, CD56- cells. Siglec9 also acts as an inhibitory receptor for MUC16 that attenuates T- andNK cell function. Recent reports suggest that Siglec9 expressed on DCs is involved in immuno regulation through ligation with mucins in an epithelial cancer patient.

Specifications

• Antigen: SIGLEC9
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: SIGLEC9
• Gene Alias: CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27180
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI8F7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9Y336
• Gene Symbols: SIGLEC9
• Immunogen: Full length human recombit protein of human SIGLEC9 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1