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Invitrogen™ SIGN-R1 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA547210
Description
In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) SIGNR3 and rmSIGNR4 is observed, and approximately 10% cross-reactivity with recombinant human DC-SIGNR and rmDC-SIGN is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.
SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase.
Specifications
SIGN-R1 | |
Polyclonal | |
Unconjugated | |
Cd209a | |
1810030I22Rik; CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; Cd209a; CD209a antigen; CD209a molecule; Cd209b; CD209b antigen; CDSIGN; CIRE; DC SIGNR1; Dcsign; DC-SIGN; DC-SIGN1; DC-SIGNR1; DC-SIGN-related protein 1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; mSIGNR1; OtB7; SIGNR1; SIGN-R1; SIGNR5 | |
Goat | |
Antigen Affinity Chromatography | |
RUO | |
170786, 69165 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Neutralization, Western Blot | |
0.2 mg/mL | |
PBS with 5% trehalose and No Preservative | |
Q8CJ91, Q91ZX1 | |
Cd209a, Cd209b | |
Mouse myeloma cell line NS0-derived recombinant mouse SIGNR1 Ser76-Gly325. | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG |
Safety and Handling
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