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Invitrogen™ SIK2 Polyclonal Antibody
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Catalog No. PIPA597005
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100 μL
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PIPA597005 100 μL
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Catalog No. PIPA597005 Supplier Invitrogen™ Supplier No. PA597005
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PPPPPPRQPG AAPAPLQFSY QTCELPSAAS PAPDYPTPCQ YPVDGAQQSD LTGPDCPRSP GLQEAPSSYD PLALSELPGL FDCEMLDAVD PQHNGYVLVN; Positive Samples: U-87MG, SW620, A-549, HeLa, Jurkat, HepG2, Mouse fat, Mouse testis, Rat testis; Cellular Location: Cytoplasm.

SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIK2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.93 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SIK2
Gene Accession No. Q8CFH6, Q9H0K1
Gene Alias G630080D20Rik; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; RGD1559698; salt induceable kinase 2; salt inducible kinase 2; salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; Sik2; SIK-2; SNF1-like kinase 2; SNF1LK2
Gene Symbols SIK2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 827-926 of human SIK2 (NP_0560061).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23235, 235344, 315649
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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