Invitrogen™ SIK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597005

Catalog No. PIPA597005

Description

Immunogen sequence: PPPPPPRQPG AAPAPLQFSY QTCELPSAAS PAPDYPTPCQ YPVDGAQQSD LTGPDCPRSP GLQEAPSSYD PLALSELPGL FDCEMLDAVD PQHNGYVLVN; Positive Samples: U-87MG, SW620, A-549, HeLa, Jurkat, HepG2, Mouse fat, Mouse testis, Rat testis; Cellular Location: Cytoplasm.

SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.

Specifications

• Antigen: SIK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIK2
• Gene Alias: G630080D20Rik; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; RGD1559698; salt induceable kinase 2; salt inducible kinase 2; salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; Sik2; SIK-2; SNF1-like kinase 2; SNF1LK2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23235, 235344, 315649
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8CFH6, Q9H0K1
• Gene Symbols: SIK2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 827-926 of human SIK2 (NP_0560061).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG