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SIK2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501563192
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20 μL
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Catalog No. Quantity
50-156-3192 20 μL
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Catalog No. 50-156-3192 Supplier Bethyl Laboratories, Inc Supplier No. A302676AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1′α and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.

Specifications

Antigen SIK2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene SIK2
Gene Accession No. Q9H0K1
Gene Alias SIK2, SNF1LK2
Gene Symbols SIK2
Host Species Rabbit
Immunogen Between 600 and 650
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23235
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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