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Invitrogen™ SIK3 Polyclonal Antibody
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Catalog No. PIPA561672
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100 μL
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PIPA561672 100 μL
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Catalog No. PIPA561672 Supplier Invitrogen™ Supplier No. PA561672
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QQEYQELFRH MNQGDAGSLA PSLGGQSMTE RQALSYQNAD SYHHHTSPQH LLQIRAQECV SQASSPTPPH GYAHQPALMH SESMEEDCSC EGAKDGFQD Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 80%.

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA). SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIK3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SIK3
Gene Accession No. Q9Y2K2
Gene Alias 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; Kiaa0999; L19; mKIAA0999; QSK; Salt-inducible kinase 3; serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK family kinase 3; SIK3; SIK-3
Gene Symbols SIK3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SIK3. Recombinant protein control fragment (Product #RP-100420).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23387
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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