Invitrogen™ SIKE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555247

Catalog No. PIPA555247

Description

Immunogen sequence: AEPVLKAHQS HSAEIESQID RICEMGEVMR KAVQVDDDQF CKIQEKLAQL ELENKELREL LSISSESLQA RKENSMD Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 90%.

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Specifications

• Antigen: SIKE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIKE1
• Gene Alias: 2810005O12Rik; 5730470L24Rik; AI450236; AI839862; RGD1311316; SIKE; SIKE1; Sikeb; suppressor of IKBKE 1; suppressor of IKK epsilon; suppressor of IKK-epsilon
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80143
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BRV8
• Gene Symbols: SIKE1
• Immunogen: Recombinant protein corresponding to Human SIKE. Recombinant protein control fragment (Product #RP-93990).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG