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Invitrogen™ SIM2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA590219
Description
Immunogen sequence: LSLEQVSTAK SQDSWRTALS TSQETRKLVK PKNTKMKTKL RTNPYPPQQY SSFQMDKLEC GQLGNWRASP PASAAAPPEL QPHSESSDLL YTPSYSLPFS YHYGHFPLDS HVFSSKKPML PAKFGQPQGS PCEVARFFLS TLPASGECQW HYANPLVPSS SSPAKNPPEP PANTARHSLV PSYE; Positive Samples: U-251MG, HepG2; Cellular Location: Nucleus.
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
Specifications
SIM2 | |
Polyclonal | |
Unconjugated | |
SIM2 | |
BHLHE15; Class E basic helix-loop-helix protein 15; HMC13F06; HMC29C01; mSIM; SIM; SIM bHLH transcription factor 2; SIM transcription factor; sim2; single-minded 2; single-minded family bHLH transcription factor 2; single-minded homolog 2; single-minded homolog 2 (Drosophila); single-minded protein; transcription factor SIM2 | |
Rabbit | |
Affinity chromatography | |
RUO | |
20465, 304071, 6493 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Western Blot | |
1.22 mg/mL | |
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
Q14190, Q61079 | |
SIM2 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_0050601?). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
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