Invitrogen™ SIM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590219

Catalog No. PIPA590219

Description

Immunogen sequence: LSLEQVSTAK SQDSWRTALS TSQETRKLVK PKNTKMKTKL RTNPYPPQQY SSFQMDKLEC GQLGNWRASP PASAAAPPEL QPHSESSDLL YTPSYSLPFS YHYGHFPLDS HVFSSKKPML PAKFGQPQGS PCEVARFFLS TLPASGECQW HYANPLVPSS SSPAKNPPEP PANTARHSLV PSYE; Positive Samples: U-251MG, HepG2; Cellular Location: Nucleus.

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

Specifications

• Antigen: SIM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SIM2
• Gene Alias: BHLHE15; Class E basic helix-loop-helix protein 15; HMC13F06; HMC29C01; mSIM; SIM; SIM bHLH transcription factor 2; SIM transcription factor; sim2; single-minded 2; single-minded family bHLH transcription factor 2; single-minded homolog 2; single-minded homolog 2 (Drosophila); single-minded protein; transcription factor SIM2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20465, 304071, 6493
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q14190, Q61079
• Gene Symbols: SIM2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_0050601?).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov